Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

Ovarian cancer is one of the most lethal gynecologic cancers. The standard therapy for
ovarian cancer has been the same for the past two decades, a combination treatment of …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Ovarian cancer is the fifth cause of cancer-related deaths in women with high grade serous
carcinoma (HGSOC) representing the most common histological subtype. Approximately …

Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is
associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and …

Metastasis, therapy failure and tumour recurrence are major clinical challenges in cancer.
The interplay between tumour‐initiating cells (TICs) and epithelial–mesenchymal transition …

The use of PARP inhibitors (PARPi) is growing widely as FDA approvals have shifted its use
from the recurrence setting to the frontline setting. In parallel, the population developing …

The tumor immune microenvironment is influenced by the epigenetic landscape of the
tumor. Here, we have identified the SETDB1–TRIM28 complex as a critical suppressor of …