Skin cancer is one of the most widespread cancers, with a significant global health effect. UV-
induced DNA damage in skin cells triggers them to grow and proliferate out of control …

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of
malignant and non-malignant disorders. CARs are synthetic transmembrane receptors …

Failure of adoptive T-cell therapies in patients with cancer is linked to limited T-cell
expansion and persistence, even in memory-prone 41BB-(BBz)–based chimeric antigen …

Introduction Metastatic rhabdomyosarcoma (RMS) is a challenging tumor entity that evades
conventional treatments and endogenous antitumor immune responses, highlighting the …

Lymphodepletion (LD) or conditioning is an essential step in the application of currently
used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it …

Osteosarcoma, the most common bone malignancy in children and adolescents, poses
considerable challenges in terms of prognosis, especially for patients with metastatic or …

Immune Checkpoint Inhibitors (ICIs) therapy has advanced significantly in treating malignant
tumors, though most 'cold'tumors show no response. This resistance mainly arises from the …

Current genome-wide studies have indicated that a great number of long non-coding RNAs
(lncRNAs) are transcribed from the human genome and appeared as crucial regulators in a …

GBM is the most aggressive and common form of primary brain cancer with a dismal
prognosis. Current GBM treatments have not improved patient survival, due to the propensity …

Aim: A novel CD19xCD3xCD28 trispecific antibody with a tandem single-chain variable
fragments (scFv) structure was developed for the treatment of B-cell malignancies. Methods …