The relevance of the‐CF2H moiety has attracted considerable attention from organic
synthetic and medicinal chemistry communities, because this group can act as a more …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Owing to the excellent performance of fluorinated compounds in the areas of
pharmaceuticals, agrochemicals, and materials chemistry, organic chemists have made …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Selective incorporation of fluorine atoms or fluorinated moieties into organic molecules has
become a routine and powerful strategy in drug design and new functional-material …

Bromodifluoromethylphosphonium bromide was solely used as the precursor of
difluorocarbene. Herein, an unprecedented visible‐light‐induced hydrodifluoromethylation …

The challenges of the modern society and the growing demand of high-technology sectors
of industrial production bring about a new phase in the development of organic synthesis. A …

We have developed a new strategy for controllable single and double difluoromethylene
(CF2) formal insertions into C− H bonds of aldehydes with nearly full selectivity under …

A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild
conditions has been developed and is based on the use of TMSCF2Br as the …