Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

D Dudzik, C Barbas-Bernardos, A García… - … of pharmaceutical and …, 2018 - Elsevier
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Ms-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines1

B Burla, M Arita, M Arita, AK Bendt… - Journal of lipid …, 2018 - ASBMB
Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in
hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) …

[PDF][PDF] A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

P Luo, P Yin, R Hua, Y Tan, Z Li, G Qiu, Z Yin… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Mass spectrometry-based plasma proteomics: considerations from sample collection to achieving translational data

V Ignjatovic, PE Geyer, KK Palaniappan… - Journal of proteome …, 2019 - ACS Publications
The proteomic analysis of human blood and blood-derived products (eg, plasma) offers an
attractive avenue to translate research progress from the laboratory into the clinic. However …

Interferences from blood collection tube components on clinical chemistry assays

RAR Bowen, AT Remaley - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Improper design or use of blood collection devices can adversely affect the
accuracy of laboratory test results. Vascular access devices, such as catheters and needles …

Effects of pre-analytical processes on blood samples used in metabolomics studies

P Yin, R Lehmann, G Xu - Analytical and bioanalytical chemistry, 2015 - Springer
Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …

Pre-analytical factors that affect metabolite stability in human urine, plasma, and serum: a review

VL Stevens, E Hoover, Y Wang, KA Zanetti - Metabolites, 2019 - mdpi.com
Metabolomics provides a comprehensive assessment of numerous small molecules in
biological samples. As it integrates the effects of exogenous exposures, endogenous …

Recommendations and best practices for standardizing the pre-analytical processing of blood and urine samples in metabolomics

R González-Domínguez, Á González-Domínguez… - Metabolites, 2020 - mdpi.com
Metabolomics can be significantly influenced by a range of pre-analytical factors, such as
sample collection, pre-processing, aliquoting, transport, storage and thawing. This therefore …