The coagulopathy of acute promyelocytic leukemia: an updated review of pathophysiology, risk stratification, and clinical management

J Hermsen, B Hambley - Cancers, 2023 - mdpi.com
Simple Summary Outcomes for patients with acute promyelocytic leukemia (APL) have
improved over the past 40 years due to the development of targeted treatment regimens and …

[HTML][HTML] Management of disseminated intravascular coagulation in acute leukemias

H Ten Cate, A Leader - Hämostaseologie, 2021 - thieme-connect.com
Disseminated intravascular coagulation (DIC) is characterized by the intravascular activation
of coagulation with loss of localization arising from different causes, and is diagnosed using …

Deep learning for diagnosis of acute promyelocytic leukemia via recognition of genomically imprinted morphologic features

JW Sidhom, IJ Siddarthan, BS Lai, A Luo… - NPJ precision …, 2021 - nature.com
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML),
classified by a translocation between chromosomes 15 and 17 [t (15; 17)], that is considered …

Coagulopathy in acute promyelocytic leukemia: can we go beyond supportive care?

BC Hambley, C Tomuleasa, G Ghiaur - Frontiers in Medicine, 2021 - frontiersin.org
Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a
distinct coagulopathy. While advances in treatments have improved long-term survival …

Hemorrhage in acute promyelocytic leukemia: Can it be predicted and prevented?

L Naymagon, J Mascarenhas - Leukemia Research, 2020 - Elsevier
Hemorrhagic death is the leading cause of treatment failure in acute promyelocytic leukemia
(APL). Our ability to identify patients at greatest risk of hemorrhage, and to actively prevent …

The role of platelets in cancer-related bleeding risk: a systematic review

JB Larsen, JA Hojbjerg, AM Hvas - Seminars in Thrombosis …, 2020 - thieme-connect.com
Cancer patients face an elevated risk of bleeding, and here platelets play a pivotal role. The
association between platelet count and bleeding, as well as safe thresholds for prophylactic …

[HTML][HTML] Clinical application of interventional embolization in tumor-associated hemorrhage

Y Chen, Y Yang, WJ Xu, YJ Xin, YN Wang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Recently, the main clinical treatment methods for tumor-associated hemorrhage include
systemic therapy, the application of hemostatic drugs, blood transfusion, symptomatic …

[HTML][HTML] 急性非早幼粒细胞白血病患者早期颅内出血预警评分系统的建立及应用

章俏雷, 叶琇锦, 方炳木, 江锦红, 刘永华, 王晓丽… - 肿瘤防治研究, 2020 - html.rhhz.net
目的回顾性分析急性非早幼粒细胞白血病(ANPL) 早期颅内出血(ICH) 的高危因素,
建立预警评分系统. 方法纳入1 281 例ANPL 成人患者(模型组) 和378 例成人患者(验证组) …

[PDF][PDF] Disseminated intravascular coagulation: An uncontrolled explosion of coagulation leading to consumptive coagulopathy

E Verigou, KC Valera, T Chatzilygeroudi, A Symeonidis - achaiki-iatriki.gr
Disseminated intravascular coagulation (DIC) is the result of an uncontrollable activation of
the coagulation cascade that can affect patients of all ages with different underlying …

Effect of Therapeutically Related Drugs on Coagulation-Anticoagulation Balance in Acute Promyelocytic Leukemia

M Xiao, P Zhou, K Sun - Clinical and Applied Thrombosis …, 2022 - journals.sagepub.com
Acute promyelocytic leukemia (APL) usually presents with a series of coagulation-
anticoagulation disturbance. Early administration of All-trans retinoic acid (ATRA) can …