Since their first demonstration of manipulation and mechanical coiling of a single DNA
molecule, magnetic tweezers have become a popular and widely used single-molecule …

The twin-supercoiled-domain model describes how transcription can drive DNA
supercoiling, and how DNA supercoiling, in turn, plays an important role in regulating gene …

Chromatin inheritance entails de novo nucleosome assembly after DNA replication by
chromatin assembly factor-1 (CAF-1). Yet direct knowledge about CAF-1's histone binding …

Acoustic-based techniques can manipulate particles in a label-free, contact-free, and
biocompatible manner. However, most previous work in acoustic manipulation has been …

CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against foreign
nucleic acids. In type I CRISPR-Cas systems, invading DNA is detected by a large …

DNA nanostructures are increasingly used for the realization of mechanically active
nanodevices and DNA-based nanorobots. A fundamental challenge in this context is the …

Magnetic force spectroscopy is a rapidly developing single molecule technique that has
found numerous applications at the interface of physics and biology. Since the invention of …

Many genome-processing reactions, including transcription, replication and repair, generate
DNA rotation. Methods that directly measure DNA rotation, such as rotor bead tracking …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Actin cytoskeleton force generation, sensing, and adaptation are dictated by the bending
and twisting mechanics of filaments. Here, we use magnetic tweezers and microfluidics to …