Oxysterols: From cholesterol metabolites to key mediators
V Mutemberezi, O Guillemot-Legris… - Progress in lipid research, 2016 - Elsevier
Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …
Lipid and lipoprotein metabolism in microglia
Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …
considered key players in the development of neuroinflammatory and neurodegenerative …
Attenuation of 7-ketocholesterol-and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age …
Age-related diseases for which there are no effective treatments include cardiovascular
diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as …
diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as …
Oxysterols: From physiological tuners to pharmacological opportunities
Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals
and ROS, or formed enzymically by a variety of enzymes such as those involved in the …
and ROS, or formed enzymically by a variety of enzymes such as those involved in the …
Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol-and 7β-hydroxycholesterol …
ketocholesterol and 7β-hydroxycholesterol are two oxysterols mainly formed by the
autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes …
autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes …
Interactions between endocrine and circadian systems
AH Tsang, JL Barclay, H Oster - Journal of molecular …, 2014 - jme.bioscientifica.com
Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …
studies, does not reside in protein-coding regions, making the identification of functional …
Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in …
Aging is characterized by a progressive increase in oxidative stress, which favors lipid
peroxidation and the formation of cholesterol oxide derivatives, including 7β …
peroxidation and the formation of cholesterol oxide derivatives, including 7β …
7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity
Oxysterols are molecules derived by the oxidation of cholesterol and can be formed either
by auto-oxidation, enzymatically or by both processes. Among the oxysterols formed by auto …
by auto-oxidation, enzymatically or by both processes. Among the oxysterols formed by auto …
Prevention of 7-ketocholesterol-induced side effects by natural compounds
Cholesterol oxidation products, also named oxysterols, can be formed either by cholesterol
auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is …
auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is …
Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications
Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol
essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the …
essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the …