Thiosemicarbazones as potent anticancer agents and their modes of action
Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …
DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?
SMV de Almeida, AG Ribeiro, GC de Lima Silva… - Biomedicine & …, 2017 - Elsevier
DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …
potential. Its key role in various cell division mechanisms, which commands the intense …
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A
R Zhang, J Xu, J Zhao, JH Bai - Journal of cellular biochemistry, 2018 - Wiley Online Library
Recent research has shown that TOP2A plays an important role in the tumorigenesis of
many malignancies, such as breast cancer, ovarian cancer, and prostate cancer. However …
many malignancies, such as breast cancer, ovarian cancer, and prostate cancer. However …
Fluorescein derived Schiff base as fluorimetric zinc (II) sensor via 'turn on'response and its application in live cell imaging
A novel Schiff base L composed of fluorescein hydrazine and a phenol functionalized moiety
has been designed and prepared via cost-effective condensation reaction. The L is utilized …
has been designed and prepared via cost-effective condensation reaction. The L is utilized …
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity
C Alonso, M Fuertes, E Martín-Encinas, A Selas… - European Journal of …, 2018 - Elsevier
This work describes the synthesis of 1, 2, 3, 4-tetrahydroquinolinylphosphine oxides,
phosphanes and phosphine sulfides as well as that of quinolinylphosphine oxides and …
phosphanes and phosphine sulfides as well as that of quinolinylphosphine oxides and …
A series of isatin-hydrazones with cytotoxic activity and CDK2 kinase inhibitory activity: a potential type II ATP competitive inhibitor
HS Al-Salem, M Arifuzzaman, HM Alkahtani… - Molecules, 2020 - mdpi.com
Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy
Z Yuan, S Chen, C Chen, J Chen, C Chen, Q Dai… - European Journal of …, 2017 - Elsevier
PARP-1 could repair the DNA damages induced by Topo inhibitors, therefore inhibiting
Topo and PARP-1 simultaneously might be able to overcome resistance and improve …
Topo and PARP-1 simultaneously might be able to overcome resistance and improve …
Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers
PH Li, H Jiang, WJ Zhang, YL Li, MC Zhao… - European Journal of …, 2018 - Elsevier
Abstract Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the
development of anticancer agents. In this study, a series of carbazole derivatives containing …
development of anticancer agents. In this study, a series of carbazole derivatives containing …
Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways
DJ Fu, L Zhang, J Song, RW Mao, RH Zhao… - European journal of …, 2017 - Elsevier
A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and
evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC …
evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC …
Synthesis, anticancer activity, and molecular modeling of new halogenated spiro [pyrrolidine-thiazolo-oxindoles] derivatives
MS Islam, AM Al-Majid, FF El-Senduny, FA Badria… - Applied Sciences, 2020 - mdpi.com
A one-pot, single-step, and an atom-economical process towards the synthesis of highly
functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory …
functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory …