The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …

The human myxovirus resistance protein 1 (MxA) is a key mediator of the interferon-induced
antiviral response against a wide range of viruses. MxA expression is tightly regulated by …

The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …

Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here,
we trace the development of these autoantibodies at high-resolution using longitudinal …

Coronaviruses are of veterinary and medical importance and include highly pathogenic
zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to efficiently evade …

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the
alpha/beta interferon (IFN-α/β) system. This virus-host interplay is dependent on the …

Avian influenza viruses (AIV) raise worldwide veterinary and public health concerns due to
their potential for zoonotic transmission. While infection with highly pathogenic AIV results in …

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of
the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The …

The human MxA gene belongs to the class of interferon (IFN)-stimulated genes (ISGs)
involved in antiviral resistance against influenza viruses. Here, we studied the requirements …

Tick-borne encephalitis virus (TBEV)(family Flaviviridae, genus Flavivirus) accounts for
approximately 10,000 annual cases of severe encephalitis in Europe and Asia. Here, we …