METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway
J Hu, K Chen, F Hong, G Gao, X Dai, H Yin - Cancer Gene Therapy, 2024 - nature.com
Liver cancer stem cells (LCSCs) contribute to tumor recurrence and cancer cell proliferation
in patients with hepatocellular carcinoma (HCC). METTL3-catalyzed m6A modification is …
in patients with hepatocellular carcinoma (HCC). METTL3-catalyzed m6A modification is …
The JMJD family of histone demethylase and their intimate links to cardiovascular disease
J Xie, H Lin, A Zuo, J Shao, W Sun, S Wang, J Song… - Cellular …, 2024 - Elsevier
The incidence rate and mortality rate of cardiovascular disease rank first in the world. It is
associated with various high-risk factors, and there is no single cause. Epigenetic …
associated with various high-risk factors, and there is no single cause. Epigenetic …
Metabolic modulation of histone acetylation mediated by HMGCL activates the FOXM1/β-catenin pathway in glioblastoma
Y Sun, G Mu, X Zhang, Y Wu, S Wang, X Wang… - Neuro …, 2024 - academic.oup.com
Background Altered branched-chain amino acid (BCAA) metabolism modulates epigenetic
modification, such as H3K27ac in cancer, thus providing a link between metabolic …
modification, such as H3K27ac in cancer, thus providing a link between metabolic …
JIB-04, an inhibitor of Jumonji histone demethylase as a potent antitubercular agent against Mycobacterium tuberculosis
P Li, Q Huang, Y Xie, Z Zhu, S Zhan, J Meng… - Archives of …, 2024 - Springer
The increasing drug resistance of Mycobacterium tuberculosis (Mtb), coupled with the
limited availability of effective anti-tuberculosis medications, poses significant challenges for …
limited availability of effective anti-tuberculosis medications, poses significant challenges for …
[HTML][HTML] Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors
TD Kim, R Gu, R Janknecht - International Journal of Biochemistry …, 2023 - ncbi.nlm.nih.gov
Objectives: Jumonji C domain-containing (JMJD) 2B (JMJD2B) is a transcriptional cofactor
and histone demethylase that is involved in prostate cancer formation. However, how its …
and histone demethylase that is involved in prostate cancer formation. However, how its …
JIB-04 通过抑制组蛋白赖氨酸去甲基化酶4 表达来调控MDM2/P53/SLC7A11/GPX4 轴诱导肝癌细胞发生铁死亡.
李健， 金俊豪， 金艳花 - Chinese Journal of Biochemistry & …, 2024 - search.ebscohost.com
摘要JIB⁃ 04 (Jumonji histone demethylase inihibitor, JIB⁃ 04) 是一种泛组蛋白赖氨酸去甲基
化酶抑制剂, 可抑制多种肿瘤发生发展, 但其具体机制仍不清楚. 本文以肝癌细胞HepG2 和Huh7 …
化酶抑制剂, 可抑制多种肿瘤发生发展, 但其具体机制仍不清楚. 本文以肝癌细胞HepG2 和Huh7 …
Computational Analysis of Rerep-Seq and Extrachromosomal Circular DNA
P Tatman - 2022 - search.proquest.com
Genomic amplifications are important in human evolution, physiology, and pathophysiology.
Rereplication is one mechanism that can produce site-specific amplifications. However …
Rereplication is one mechanism that can produce site-specific amplifications. However …