Emerging impact of triazoles as anti-tubercular agent
A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …
Isocyanide based [4+ 1] cycloaddition reactions: an indispensable tool in multi-component reactions (MCRs)
The advent of cycloaddition reactions in the synthesis of heterocycles and their ever
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …
Coumarin–triazole hybrids and their biological activities
YL Fan, X Ke, M Liu - Journal of Heterocyclic Chemistry, 2018 - Wiley Online Library
Hybridization is emerged as a promising strategy in the discovery of new drugs, especially
these with complimentary activities and multiple pharmacological targets that are the …
these with complimentary activities and multiple pharmacological targets that are the …
Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …
disease which results in approximately 10 million incident cases and 1.4 million deaths …
One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents
Propargylthiobenzimidazole 1, 4-bromomethyl coumarins/1-aza-coumarins 2/3 and sodium
azide have been reacted in one pot under Click chemistry conditions to give exclusively 1, 4 …
azide have been reacted in one pot under Click chemistry conditions to give exclusively 1, 4 …
Targeting bacterial topoisomerases: how to counter mechanisms of resistance
YC Tse-Dinh - Future Medicinal Chemistry, 2016 - Taylor & Francis
DNA gyrase and topoisomerase IV are type IIA bacterial topoisomerases that are targeted by
highly effective antibiotics. However, resistance via multiple mechanisms arises to limit the …
highly effective antibiotics. However, resistance via multiple mechanisms arises to limit the …
Target-based approaches for the discovery of new antimycobacterial drugs
Highlights•The most recently studied drug targets are reviewed.•The protein–protein
interaction network was generated using STRING database.•Hits and leads were discovered …
interaction network was generated using STRING database.•Hits and leads were discovered …
Versatility of 7-substituted coumarin molecules as antimycobacterial agents, neuronal enzyme inhibitors and neuroprotective agents
A medium-throughput screen using Mycobacterium tuberculosis H37Rv was employed to
screen an in-house library of structurally diverse compounds for antimycobacterial activity. In …
screen an in-house library of structurally diverse compounds for antimycobacterial activity. In …
Embryonic and larval zebrafish models for the discovery of new bioactive compounds against TB
TB is a world health challenge the treatment of which is impacted by the rise of drug-
resistant strains. Thus, there is an urgent need for new antitubercular compounds and novel …
resistant strains. Thus, there is an urgent need for new antitubercular compounds and novel …
Chemical classes targeting energy supplying GyrB domain of Mycobacterium tuberculosis
Tuberculosis (TB) is contagious in nature and immunocompromised patients have a higher
probability of developing TB. The occurrence of drug resistance, has led to serious health …
probability of developing TB. The occurrence of drug resistance, has led to serious health …