Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

Excitatory activity in the CNS is predominately mediated by l-glutamate through several
families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate …

Different types of memory are thought to rely on different types of synaptic plasticity, many of
which depend on the activation of the N-Methyl-D Aspartate (NMDA) subtype of glutamate …

Allosteric modulators of ion channels typically alter the transitions rates between
conformational states without changing the properties of the open pore. Here we describe a …

Ion channels have been characterized as promising drug targets for treatment of numerous
human diseases. Functions of ion channels can be fine-tuned by allosteric modulators …

Selective disruption of synaptic drive to inhibitory neurons could contribute to the
pathophysiology of various brain disorders. We have previously identified a GluN2A …

N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated Na+ and Ca2+-permeable
ion channels involved in excitatory synaptic transmission and synaptic plasticity. NMDAR …

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated cation channels that
mediate excitatory neurotransmission and are critical for synaptic development and plasticity …

N-methyl-d-aspartate receptors (NMDARs) have multiple prominent roles in CNS function
but their excessive or insufficient activity contributes to neuropathological/psychiatric …