[HTML][HTML] Simulation-based approaches for drug delivery systems: navigating advancements, opportunities, and challenges

I Salahshoori, M Golriz, MAL Nobre, S Mahdavi… - Journal of Molecular …, 2023 - Elsevier
Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

Measurement uncertainty and conformity assessment applied to drug and medicine analyses–a review

L Separovic, RS Simabukuro, AR Couto… - Critical Reviews in …, 2023 - Taylor & Francis
Analytical results are often used in scientific research, industrial and clinical applications to
support decision making. Despite all efforts to ensure the reliability of analytical results …

Modeling the diffusion-erosion crossover dynamics in drug release

MS Gomes-Filho, FA Oliveira, MAA Barbosa - Physical Review E, 2022 - APS
A computational model is proposed to investigate drug delivery systems in which erosion
and diffusion mechanisms are participating in the drug release process. Our approach …

Intelligent and probabilistic models for evaluating the release of food bioactive ingredients from carriers/nanocarriers

N Malekjani, SM Jafari - Food and Bioprocess Technology, 2022 - Springer
Release modeling is an important issue in designing controlled release systems for food
bioactive compounds and nutraceuticals in order to elucidate the underlying mechanisms …

A statistical mechanical model for drug release: Relations between release parameters and porosity

MS Gomes-Filho, MAA Barbosa, FA Oliveira - Physica A: Statistical …, 2020 - Elsevier
A lattice gas model is proposed for investigating the release of drug molecules on devices
with semi-permeable, porous membranes in two and three dimensions. The kinetic of this …

Measurement uncertainty estimation based on multiple regression analysis (MRA) and Monte Carlo (MC) simulations–Application to agar diffusion method

AM Saviano, FR Lourenço - Measurement, 2018 - Elsevier
The agar diffusion method is well known in the scientific literature, but it presents as a
disadvantage the high variability. Despite of this, as far as we know, the main sources of …

Microstructure-based mathematical modelling and spectroscopic imaging of tablet dissolution

JA Kimber, SG Kazarian, F Štěpánek - Computers & chemical engineering, 2011 - Elsevier
A computer model was developed with the objective of modelling pharmaceutical tablet
dissolution with non-swelling excipients. The model, which allows the explicit description of …

Personality development across the adult life span: Subjective conceptions vs cross-sectional contrasts

J Krueger, J Heckhausen - Journal of Gerontology, 1993 - academic.oup.com
This research examined possible contributions of subjective conceptions about
development to the study of long-term personality stability and change. Young, middle-aged …

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

KS Pang, M Weiss, P Macheras - The AAPS Journal, 2007 - Springer
Three advanced models of pharmacokinetics are described. In the first class are
physiologically based pharmacokinetic models based on in vitro data on transport and …

Monte Carlo simulations for the study of drug release from matrices with high and low diffusivity areas

K Kosmidis, P Macheras - International journal of pharmaceutics, 2007 - Elsevier
We use Monte Carlo simulations in order to study diffusion controlled drug release from
matrices consisting of random mixtures of high and low diffusivity areas (random mixing) …