Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma
patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds …

Background TXA is a synthetic lysine derivative that exerts its action by competitively
occupying the lysine binding site of plasminogen, thereby blocking interaction with fibrin and …

Objective To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the
antifibrinolytic tranexamic acid on survival in combat injured. Design Retrospective …

Objective: To characterize the relationship between tranexamic acid (TXA) use and patient
outcomes in a severely injured civilian cohort, and to determine any differential effect …

Importance Since publication of the CRASH-2 and MATTERs studies, the US military has
included tranexamic acid (TXA) in clinical practice guidelines. While TXA was shown to …

Long-term anticoagulation treatment with warfarin has been associated with a number of
limitations in clinical practice and there is a need for more convenient long-term …

ABSTRACT A recent large civilian randomized controlled trial on the use of tranexamic acid
(TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA …

Advancements in trauma care have been made because of improvements in blood storage,
prehospital and interhospital transport systems, and refinement of resuscitative and surgical …

A number of concerns have been raised regarding the advisability of the classic principles of
aggressive crystalloid resuscitation in traumatic hemorrhagic shock. This issue reviews the …

Background The leading cause of preventable death in the military setting is haemorrhage.
Accumulating evidence has established the benefit of tranexamic acid (TXA), an …