Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …

The RNA modification N 6-methyladenosine (m 6 A) modulates mRNA fate and thus affects
many biological processes. We analyzed m 6 A across the transcriptome following infection …

Hepatitis C virus (HCV) infection is still a major public health problem worldwide since its
first identification in 1989. At the start, HCV infection was post-transfusion viral infection …

All major types of interferon (IFN) efficiently inhibit hepatitis C virus (HCV) replication in vitro
and in vivo. Remarkably, HCV replication is not sensitive to IFN-γ in the hepatoma cell line …

Hepatitis C virus (HCV) is the cause of one of the most prevalent viral infections worldwide.
Upon infection, the HCV genome activates the RIG‐I‐MAVS signalling pathway leading to …

Abstract background and purpose Celastrol, a quinone methide triterpene isolated from the
root extracts of Tripterygium wilfordii, can greatly induce the gene expression activity of …

Dengue virus (DV) is a positive-strand RNA virus of the Flavivirus genus. It is one of the most
prevalent mosquito-borne viruses, infecting globally 390 million individuals per year. The …

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is
also known to possess other functions including protein trafficking and anti-microbial …

Hepatitis C virus (HCV) remains a significant global health challenge. Approximately 50
million people were living with chronic hepatitis C based on the World Health Organization …

Like all positive-sense RNA viruses, hepatitis C virus (HCV) induces host membrane
alterations for its replication termed the membranous web (MW). Assembling replication …