Following a period of slow progress, the completion of genome sequencing and the
paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led …

Background Ovarian cancer poses a serious threat to women's health. Due to the difficulty of
early detection, most patients are diagnosed with advanced-stage disease or peritoneal …

Reproducibility is a “proteomic dream” yet to be fully realized. A typical data analysis
workflow utilizing extracted ion chromatograms (XICs) often treats the information path from …

Purpose This study evaluated the efficacy and safety in a real-world population of epithelial
ovarian cancer (EOC) treated with poly (ADP-ribose) polymerase inhibitor (PARPi) as first …

Biallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of
metastatic castration-resistant prostate cancer (mCRPC). It remains unclear, however …

Patients with High-Grade Serous Ovarian Cancer (HGSOC) exhibit varied responses to
treatment, with 20-30% showing de novo resistance to platinum-based chemotherapy. While …

Background: Tumor heterogeneity is associated with poor prognosis and drug resistance,
leading to therapeutic failure. Here, we aim to utilize tumor evolution analysis to decode the …

Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian
cancer etiology, early detection, and treatment is understood. However, previous GEMMs of …

Ovarian high-grade serous carcinoma (HGSC) represents the deadliest gynecological
malignancy, with 10-15% of patients exhibiting primary resistance to first-line chemotherapy …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic form of vascular cognitive …