[HTML][HTML] Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence

TN McNeilly, AJ Nisbet - Parasite, 2014 - ncbi.nlm.nih.gov
Parasitic helminths reside in immunologically-exposed extracellular locations within their
hosts, yet they are capable of surviving for extended periods. To enable this survival, these …

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules

MJG Johnston, JA MacDonald, DM McKay - Parasitology, 2009 - cambridge.org
Infection with parasitic helminths takes a heavy toll on the health and well-being of humans
and their domestic livestock, concomitantly resulting in major economic losses. Analyses …

Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A

J Rzepecka, S Rausch, C Klotz, C Schnöller… - Molecular …, 2009 - Elsevier
Helminth infections are commonly associated with a Th2 immune response, yet only a few
parasite molecules involved in triggering such immune responses have been identified …

Glyceraldehyde‐3‐phosphate dehydrogenase of the parasitic nematode Haemonchus contortus binds to complement C3 and inhibits its activity

S Sahoo, S Murugavel, IK Devi… - Parasite …, 2013 - Wiley Online Library
H aemonchus contortus is an economically important gastrointestinal parasite that infects
primarily sheep and goats. To survive inside the host, the parasite must overcome the host …

The many faces of parasite calreticulin

D Esperante, A Flisser, F Mendlovic - Frontiers in Immunology, 2023 - frontiersin.org
Calreticulin from parasites and its vertebrate hosts share~ 50% identity and many of its
functions are equally conserved. However, the existing amino acid differences can affect its …

Modulation of dendritic cell responses by parasites: a common strategy to survive

CA Terrazas, LI Terrazas… - BioMed Research …, 2010 - Wiley Online Library
Parasitic infections are one of the most important causes of morbidity and mortality in our
planet and the immune responses triggered by these organisms are critical to determine …

The interactions of parasite calreticulin with initial complement components: consequences in immunity and virulence

G Ramírez-Toloza, L Aguilar-Guzmán, C Valck… - Frontiers in …, 2020 - frontiersin.org
Because of its capacity to increase a physiologic inflammatory response, to stimulate
phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the …

Functional diversity of the excretory/secretory proteins of nematode parasites

P Joshi, PKK Mishra - Acta Parasitologica, 2022 - Springer
Introduction Parasites release a wide array of protein as excretory and secretory products
(ESPs). Irrespective of their mode of propagation, ESPs are found to be secreted or excreted …

Trypanosoma carassii calreticulin binds host complement component C1q and inhibits classical complement pathway-mediated lysis

A Oladiran, M Belosevic - Developmental & Comparative Immunology, 2010 - Elsevier
Trypanosoma carassii is an extracellular parasite of economically important fish species that
has evolved several strategies to circumvent host immune responses. Proteomic analysis of …

The analysis of the acute phase response during the course of Trypanosoma carassii infection in the goldfish (Carassius auratus L.)

N Kovacevic, MO Hagen, J Xie, M Belosevic - … & Comparative Immunology, 2015 - Elsevier
The expression of genes encoding the acute phase proteins (APP) during the course of
Trypanasoma carassii infection in the goldfish was determined using quantitative PCR …