Caffeine and its antioxidant properties—it is all about dose and source

BE Ősz, G Jîtcă, RE Ștefănescu, A Pușcaș… - International journal of …, 2022 - mdpi.com
Caffeine is the most frequently used substance with a central nervous system stimulant
effect, but its consumption is most often due to the intake of foods and drinks that contain it …

[HTML][HTML] Aspartame—true or false? Narrative review of safety analysis of general use in products

K Czarnecka, A Pilarz, A Rogut, P Maj, J Szymańska… - Nutrients, 2021 - mdpi.com
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was
discovered by James M. Schlatter in 1965. Being 180–200 times sweeter than sucrose, its …

Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala

SK Jones, DM McCarthy, C Vied… - Proceedings of the …, 2022 - National Acad Sciences
We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and
gene expression in the amygdala, a brain region associated with the regulation of anxiety …

Aspartame safety as a food sweetener and related health hazards

SAA Shaher, DF Mihailescu, B Amuzescu - Nutrients, 2023 - mdpi.com
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has
become a very popular artificial sweetener. However, since its approval by the main food …

[HTML][HTML] Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

SJ Borghoff, SS Cohen, X Jiang, IA Lea… - Food and Chemical …, 2023 - Elsevier
Aspartame has been studied extensively and evaluated for its safety in foods and beverages
yet concerns for its potential carcinogenicity have persisted, driven primarily by animal …

Daily early-life exposures to diet soda and aspartame are associated with autism in males: A case-control study

SP Fowler, D Gimeno Ruiz de Porras, MD Swartz… - Nutrients, 2023 - mdpi.com
Since its introduction, aspartame—the leading sweetener in US diet sodas (DS)—has been
reported to cause neurological problems in some users. In prospective studies, the offspring …

An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety

MA Farag, MM Rezk, MH Elashal, M El-Araby… - Food Research …, 2022 - Elsevier
Artificial sweeteners have become increasingly popular worldwide owing to their lower
calorie content in addition to the claims of health benefits such as weight control, blood …

Aspartame and its metabolites cause oxidative stress and mitochondrial and lipid alterations in SH-SY5Y cells

LV Griebsch, EL Theiss, D Janitschke, VKJ Erhardt… - Nutrients, 2023 - mdpi.com
Due to a worldwide increase in obesity and metabolic disorders such as type 2 diabetes,
synthetic sweeteners such as aspartame are frequently used to substitute sugar in the diet …

Aspartame consumption during pregnancy impairs placenta growth in mice through sweet taste receptor-reactive oxygen species-dependent pathway

SY Huang, R Sun, YC Chen, L Kang, CT Wang… - The Journal of …, 2023 - Elsevier
The prevalence of obesity has risen dramatically over recent years, and so has the
prevalence of adverse obesity-associated pregnancy outcomes. To combat obesity, the …

The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats

V Suswidiantoro, NU Azmi, D Lukmanto, FC Saputri… - Heliyon, 2023 - cell.com
Aspartame is widely used artificial sweetener. However, chronic exposure to aspartame led
to spatial memory impairment and elevated oxidative stress in the brain. Extract of turmeric …