IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)

LS Feng, WQ Su, JB Cheng, T Xiao, HZ Li… - Archiv der …, 2022 - Wiley Online Library

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

被引用次数：35 相关文章所有 4 个版本

Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer

RD Cervantes-Villagrana, I García-Jiménez… - Cellular …, 2023 - Elsevier

Metastatic cancer cells dynamically adjust their shape to adhere, invade, migrate, and
expand to generate secondary tumors. Inherent to these processes is the constant assembly …

被引用次数：10 相关文章所有 3 个版本

[PDF] aacrjournals.org

Characterization of novel derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42

JI Medina, A Cruz-Collazo, MM Maldonado… - Cancer research …, 2022 - AACR

Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell-
cycle progression; thus, representing key targets for metastasis therapy. We previously …

被引用次数：8 相关文章所有 9 个版本

Elucidation of mode of anticancerous activity of metal guanidinobenzimidazoles: A computational and experimental screening

E Jabeen, MS Khan, Z Qazi, K Ghani… - Applied …, 2024 - Wiley Online Library

DNA‐binding agents often exhibits dual behavior of simultaneous binding with protein
associated with cancerous cell development pathways. This simultaneous protein binding if …

被引用次数：1 相关文章

[PDF] nature.com

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic …

S Hegde, A Gasilina, M Wunderlich, Y Lin… - Leukemia, 2022 - nature.com

Aberrant RHO guanine nucleotide exchange factor (RhoGEF) activation is chief mechanism
driving abnormal activation of their GTPase targets in transformation and tumorigenesis …

被引用次数：6 相关文章所有 4 个版本

[HTML] anserpress.org

[HTML][HTML] Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics

F Movahedi, L Li, ZP Xu - Cancer Insight, 2023 - anserpress.org

Cancer chemotherapy is generally associated with many severe adverse effects. Many
cancer studies are currently focused on repurposing conventional non-toxic anti-parasite …

被引用次数：3 相关文章所有 3 个版本

被引用次数：1 相关文章所有 4 个版本

[PDF] ohiolink.edu

Design, Synthesis and Biological Evaluation of New Molecules to Selectively Target Specific Cancers

G Premnauth - 2020 - search.proquest.com

Cancer remains one of the leading causes of mortality in the world. Even with the
improvement of treatments in multiple type of cancer, current chemotherapies are highly …

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