Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Harnessing transition metal scaffolds for targeted antibacterial therapy

C Weng, YLK Tan, WG Koh… - Angewandte Chemie …, 2023 - Wiley Online Library
Antimicrobial resistance, caused by persistent adaptation and growing resistance of
pathogenic bacteria to overprescribed antibiotics, poses one of the most serious and urgent …

The potential use of bacteria and bacterial derivatives as drug delivery systems for viral infection

A Faghihkhorasani, HH Ahmed, NM Mashool, M Alwan… - Virology Journal, 2023 - Springer
Viral infections in humans are responsible for fatalities worldwide and contribute to the
incidence of various human ailments. Controllable targeted medicine delivery against many …

Cloaking mesoporous polydopamine with bacterial membrane vesicles to amplify local and systemic antitumor immunity

W Chen, Y Song, S Bai, C He, Z Guo, Y Zhu, Z Zhang… - ACS …, 2023 - ACS Publications
As adjuvants or antigens, bacterial membranes have been widely used in recent
antibacterial and antitumor research, but they are often injected multiple times to achieve …

Biomimetic active materials guided immunogenic cell death for enhanced cancer immunotherapy

G Huang, L Liu, H Pan, L Cai - Small Methods, 2023 - Wiley Online Library
Despite immunotherapy emerging as a vital approach to improve cancer treatment, the
activation of efficient immune responses is still hampered by immunosuppression, especially …

An updated review on oral protein-based antigen vaccines efficiency and delivery approaches: a special attention to infectious diseases

P Hashemi, S Mahmoodi, A Ghasemian - Archives of Microbiology, 2023 - Springer
Various infectious agents affect human health via the oral entrance. The majority of
pathogens lack approved vaccines. Oral vaccination is a convenient, safe and cost-effective …

[HTML][HTML] Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

L Yu, S Liu, S Jia, F Xu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The management and treatment of disease are achieved via the use of pharmacologically
active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; …

Potentiating the Systemic Immunity by Bacteria‐Delivered Sting Activation in a Tumor Microenvironment

W Chen, Y Zhu, J Chen, X Jing, Y Xiong… - Advanced Functional …, 2023 - Wiley Online Library
Stimulator of interferon genes (STING) connects the innate immunity to potent adaptive
immunity via multiple pathways, which play a critical role in cancer treatment. Clinical …

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

L Zhao, J Chen, B Bai, G Song, J Zhang, H Yu… - Frontiers in …, 2024 - frontiersin.org
Topical drug delivery is widely used in various diseases because of the advantages of not
passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first …