The emerging importance of lymphatics in health and disease: an NIH workshop report

BJ Mehrara, AJ Radtke, GJ Randolph… - The Journal of …, 2023 - Am Soc Clin Investig
The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

The evolving cardiac lymphatic vasculature in development, repair and regeneration

K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

CL Walsh, P Tafforeau, WL Wagner, DJ Jafree… - Nature …, 2021 - nature.com
Imaging intact human organs from the organ to the cellular scale in three dimensions is a
goal of biomedical imaging. To meet this challenge, we developed hierarchical phase …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Promoting lymphangiogenesis and lymphatic growth and remodeling to treat cardiovascular and metabolic diseases

X Liu, K Cui, H Wu, KS Li, Q Peng, D Wang… - … , and vascular biology, 2023 - Am Heart Assoc
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in
the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake …

Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures

S Fleig, T Kapanadze, J Bernier-Latmani, JK Lill… - Nature …, 2022 - nature.com
Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge
during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains …

The lymphatics in kidney health and disease

MD Donnan, Y Kenig-Kozlovsky… - Nature Reviews …, 2021 - nature.com
The mammalian vascular system consists of two networks: the blood vascular system and
the lymphatic vascular system. Throughout the body, the lymphatic system contributes to …

Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney

E Yagis, S Aslani, Y Jain, Y Zhou, S Rahmani… - Scientific Reports, 2024 - nature.com
Automated blood vessel segmentation is critical for biomedical image analysis, as vessel
morphology changes are associated with numerous pathologies. Still, precise segmentation …

Mechanisms and cell lineages in lymphatic vascular development

DJ Jafree, DA Long, PJ Scambler, C Ruhrberg - Angiogenesis, 2021 - Springer
Lymphatic vessels have critical roles in both health and disease and their study is a rapidly
evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in …

Cellular origins of the lymphatic endothelium: implications for cancer lymphangiogenesis

L Gutierrez-Miranda, K Yaniv - Frontiers in Physiology, 2020 - frontiersin.org
The lymphatic system plays important roles in physiological and pathological conditions.
During cancer progression in particular, lymphangiogenesis can exert both positive and …