Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy

D D'Eliseo, F Velotti - Journal of clinical medicine, 2016 - mdpi.com
Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Primary prevention of colorectal cancer

AT Chan, EL Giovannucci - Gastroenterology, 2010 - Elsevier
Colorectal cancer has been strongly associated with a Western lifestyle. In the past several
decades, much has been learned about the dietary, lifestyle, and medication risk factors for …

Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

K Jing, KS Song, S Shin, N Kim, S Jeong, HR Oh… - Autophagy, 2011 - Taylor & Francis
Docosahexaenoic acid (DHA) has been reported to induce tumor cell death by apoptosis.
However, little is known about the effects of DHA on autophagy, another complex well …

The omega‐3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS‐mediated Akt‐mTOR signaling in prostate …

S Shin, K Jing, S Jeong, N Kim, KS Song… - BioMed research …, 2013 - Wiley Online Library
Docosahexaenoic acid (DHA) induces autophagy‐associated apoptotic cell death in wild‐
type p53 cancer cells via regulation of p53. The present study investigated the effects of …

MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin

J Zhang, C Han, T Wu - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: MicroRNAs (miRNAs) have been implicated in the development
and progression of human cancers. We investigated the roles and mechanisms of miR-26a …

Roles of the unsaturated fatty acid docosahexaenoic acid in the central nervous system: Molecular and cellular insights

AB Petermann, M Reyna-Jeldes, L Ortega… - International journal of …, 2022 - mdpi.com
Fatty acids (FAs) are essential components of the central nervous system (CNS), where they
exert multiple roles in health and disease. Among the FAs, docosahexaenoic acid (DHA) …

[HTML][HTML] Wnt/β-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation

T Yamada, S Hasegawa, Y Inoue, Y Date… - Journal of Investigative …, 2013 - Elsevier
UV radiation is a well-known inducer of epidermal pigmentation that is utilized in therapy for
vitiligo, one of the skin depigmentation disorders. Although it has been reported that …

Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms

WKK Wu, JJY Sung, CW Lee, J Yu, CH Cho - Cancer letters, 2010 - Elsevier
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE 2 -dependent mechanisms

JR Neil, KM Johnson, RA Nemenoff… - …, 2008 - academic.oup.com
Although it is well established that mammary tumorigenesis converts transforming growth
factor-β (TGF-β) from a tumor suppressor to a tumor promoter, the molecular, cellular and …

Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?

H Gleissman, JI Johnsen, P Kogner - Experimental cell research, 2010 - Elsevier
Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional
chemotherapeutics are considered “double-edged swords”, as they kill the cancer cells but …