Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Beneath the complexity and idiopathy of every cancer lies a limited number of'mission
critical'events that have propelled the tumour cell and its progeny into uncontrolled …

Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to …

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a
potential anticancer agent. However, considerable numbers of cancer cells, especially some …

Interactions between the immune system and malignant cells play an important role in
tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead …

Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …