Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …

The rapid synthesis of cyclic scaffolds is of high importance to the chemistry community.
Strategies for the convergent synthesis of substituted carbocycles and heterocycles remain …

Ene‐reductases from the Old Yellow Enzyme (OYE) superfamily are a well‐known and
efficient biocatalytic alternative for the asymmetric reduction of C= C bonds. Considering the …

Redox enzymes offer many powerful transformations for the efficient industrial-scale
synthesis of diverse chemicals desired by society. Here we survey recent preparative …

Radical chemistry has played an important role in organic synthetic chemistry in the past
decades. Additionally, the combination of N-heterocyclic carbene (NHC) catalysis and …

The unmatched chemo-, regio-, and stereoselectivity of enzymes renders them powerful
catalysts in the synthesis of chiral active pharmaceutical ingredients (APIs). Inspired by the …

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting
enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of …