Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-
enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about …

Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

Aging is characterized by a progressive increase in oxidative stress, which favors lipid
peroxidation and the formation of cholesterol oxide derivatives, including 7β …

Mutations in the chromatin remodeller‐coding gene CHD7 cause CHARGE syndrome (CS).
CS features include moderate to severe neurological and behavioural problems, clinically …

Abstract 24 (S)-Hydroxycholesterol (24S-OHC) and 25-hydroxycholesterol (25-OHC) are
produced by cholesterol 24-hydroxylase and cholesterol 25-hydroxylase, respectively. The …

Cholesterol is a key molecule for synaptic transmission, and both central and peripheral
synapses are cholesterol rich. During intense neuronal activity, a substantial portion of …

Introduction Oxysterols are cholesterol oxidation products and bioactive lipids involved in
developmental signalling pathways, embryonic and postembryonic tissue patterning and …

Zebrafish is an in vivo model used in toxicology to estimate the effects of xenobiotics and
their teratogenic consequences. The knowledge of the oxysterols profile in zebrafish, during …

Oxysterols have long been considered as simple by-products of cholesterol metabolism, but
they are now fully designed as bioactive lipids that exert their multiple effects through their …

O cérebro é um órgão rico em colesterol, onde o mesmo pode atuar na integração de
membranas celulares e formar baínhas de mielina. A barreira hematoencefálica (BBB) …