Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

Nematode chitinases are critical components of the nematode life cycle, and Ce Cht1 is a
potential target for developing novel nematicides. Herein, lunidonine, a natural quinoline …

As a complement to virtual screening, de novo design of small molecules is an alternative
approach for identifying potential drug candidates. Here, we present a new 3D genetic …

Insect growth regulators (IGRs) disrupt normal development of physiological processes in
insects and are recognized as green insecticides. Insect chitinases play a crucial role in …

Fatty acid binding protein 5 (FABP5) is a promising target for development of inhibitors to
help control pain and inflammation. In this work, computer-based docking (DOCK6 program) …

Here, the synthesis, photophysical characterization, and application of a new size‐
expanded thymine nucleoside, dioxT, is described. dioxT has desirable qualities as a T …

Two new series of N-aryl acetamides 6a-o and benzyloxy benzylidenes 9a-p based 2-
oxoindole derivatives were designed as potent antiproliferative multiple kinase inhibitors …

Botulinum neurotoxins (BoNT) are among the most poisonous substances known, and of the
7 serotypes (A–G) identified thus far at least 4 can cause death in humans. The goal of this …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) an enveloped, positive-
sense single-stranded RNA virus that is responsible for the COVID-19 pandemic. The viral …

The World Health Organization has designated Zika virus (ZIKV) as a dangerous, mosquito-
borne pathogen that can cause severe developmental defects. The primary goal of this work …