Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI),
remains a major cause of mortality worldwide. Despite the development of effective pre …

Since the initial description of the phenomenon by Jennings et al 50 years ago, our
understanding of the underlying mechanisms of reperfusion injury has grown significantly …

Cardiovascular disease is a major target for many experimental stem cell-based therapies
and mesenchymal stem cells (MSCs) are widely used in these therapies. Transplantation of …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …

Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Despite nearly twenty years of research into the field of ischemic preconditioning, the actual
mechanism of protection remains unclear. However, much progress has been made in …

In recent years, major advances have been made toward understanding the role of nitric
oxide (NO) in the ischemic biology of the heart. It is now clear that NO, either endogenous or …

Objectives A series of brief coronary artery reperfusions and reocclusions applied during the
early minutes of coronary artery reflow (“postconditioning”) attenuates reperfusion injury …