Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy

S Zhang, L Wang, Y Kang, J Wu, Z Zhang - Acta Biomaterialia, 2023 - Elsevier
Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …

Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

M Huang, Q Teng, F Cao, J Huang, J Pang - Biomaterials Science, 2024 - pubs.rsc.org
Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors.
However, single treatment modalities are often restricted due to biochemical recurrence and …

Triple Tumor Microenvironment‐Responsive Ferroptosis Pathways Induced by Manganese‐Based Imageable Nanoenzymes for Enhanced Breast Cancer …

H He, L Du, H Xue, Y An, K Zeng, H Huang… - Small …, 2023 - Wiley Online Library
Previous studies have found that activated CD8+ T cells secrete elevated levels of interferon‐
gamma (IFN‐γ) to trigger ferroptosis in tumor cells. However, IFN‐γ‐mediated ferroptosis is …

GPX4 inhibition synergistically boosts mitochondria targeting nanoartemisinin-induced apoptosis/ferroptosis combination cancer therapy

H Yu, JM Li, K Deng, W Zhou, KH Li, CX Wang… - Biomaterials …, 2023 - pubs.rsc.org
Artemisinin, originally used for its antimalarial activity, has received much attention in recent
years for cancer therapy. The anticancer mechanisms of artemisinin are complicated and …

Restoring cellular calcium homeostasis to rescue ER stress by 1, 2-bis (2-aminophenoxy) ethane-N, N, N′, N′-tetraacetic acid acetoxymethyl ester-loaded lipid …

J Zhang, J Yan, Y Wang, H Liu, X Sun, Y Gu, L Yu… - Chinese Chemical …, 2024 - Elsevier
Early pathogenesis of ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) is
dominated by intracellular calcium overload, which induces oxidative stress, intracellular …

Impact of poly (ester amide) structure on properties and drug delivery for prostate cancer therapy

J Zhang, L Wang, M Ding, X You, J Wu, J Pang - BME frontiers, 2023 - spj.science.org
Objective: We aim to develop a polymer library consisting of phenylalanine-based poly
(ester amide) s (Phe-PEAs) for cancer therapy and investigate the structure–property …

Facile synthesis of poly (disulfide) s through one-step oxidation polymerization for redox-responsive drug delivery

R Zhang, T Nie, L Wang, D He, Y Kang, C Zhang… - Biomaterials …, 2023 - pubs.rsc.org
Poly (disulfide) s-based systems with repetitive disulfide bonds in their backbones are
emerging as promising tumor microenvironment responsive platforms for drug delivery …

Development of a lysine-based poly (ester amide) library with high biosafety and a finely tunable structure for spatiotemporal-controlled protein delivery

S Han, J Wu - ACS Applied Materials & Interfaces, 2022 - ACS Publications
With the fast growth of protein therapeutics, efficient, precise, and universal delivery
platforms are highly required. However, very few reports have discussed the progress of …

Nano-silver-modified polyphosphazene nanoparticles with different morphologies: Design, synthesis, and evaluation of antibacterial activity

T Kuang, L Deng, S Shen, H Deng, Z Shen, Z Liu… - Chinese Chemical …, 2023 - Elsevier
Drug-resistant bacteria present a severe threat to public health, emphasizing the importance
of developing broad-spectrum antibacterial agents that are free from drug resistance. Among …

Applications of nanomaterials in endometriosis treatment

J Yuxue, S Ran, F Minghui, S Minjia - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Endometriosis is a common disease of the reproductive system in women of childbearing
age with an unclear pathogenesis. Endometriosis mainly manifests as dysmenorrhea …