Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Azapeptides are peptide analogs in which one or more of the amino residues is replaced by
a semicarbazide. This substitution of a nitrogen for the α-carbon center results in …

Abstract Pancreatic ribonuclease A (EC 3.1. 27.5, RNase) is, perhaps, the best‐studied
enzyme of the 20th century. It was isolated by René Dubos, crystallized by Moses Kunitz …

The cis− trans isomerization of prolyl amide bonds results in large structural and functional
changes in proteins and is a rate-determining step in protein folding. We describe a novel …

Gramicidin S, natural antimicrobial peptide is used commercially in medicinal lozenges for
sore throat and Gram-negative and Gram-positive bacterial infections. However, its clinical …

We report herein the first systematic crystal structural investigation of azaproline
incorporated in homo‐and heterochiral diprolyl peptides. The X‐ray crystallography data of …

Protein–protein interactions are ubiquitous, essential to almost all known biological
processes, and offer attractive opportunities for therapeutic intervention. Developing small …

Theoretical calculations at the B3LYP-D3 (BJ)/6–311++ G (d, p) level of a series of 35
neutral pyrazolidines and 3 protonated derivatives have been carried out for different …

Four residues making almost a complete 180° turn in the direction of the peptide chain
define a reverse turn, a common motif and recognition site in proteins. Cyclization between …

Proline residues have long been recognized to play a unique and important role in the
structural properties of peptides and proteins. The cis/trans isomerization of the aminoacyl …