Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Abstract siRNA‐mediated management of myocardial ischemia reperfusion (IR) injury is
greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection …

Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists
of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Cardiac fibrosis is characterized by a maladaptive remodeling of the myocardium, which is
controlled by various inflammatory pathways and cytokines. This remodeling is …

Ex vivo modelling systems for cardiovascular research are becoming increasingly important
in reducing lab animal use and boosting personalized medicine approaches. Integrating …

The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif
(YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key …

The application of biomimetic physical stimuli replicating the in vivo dynamic
microenvironment is crucial for the in vitro development of functional cardiac tissues. In …