The Akt pathway in oncology therapy and beyond

GM Nitulescu, M Van De Venter… - International …, 2018 - spandidos-publications.com
Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

[HTML][HTML] Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

A Banerjee, S Mukherjee, BK Maji - Toxicology Reports, 2021 - Elsevier
In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …

Chronic inflammation in the context of everyday life: dietary changes as mitigating factors

D Margină, A Ungurianu, C Purdel… - International journal of …, 2020 - mdpi.com
The lifestyle adopted by most people in Western societies has an important impact on the
propensity to metabolic disorders (eg, diabetes, cancer, cardiovascular disease …

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease

D Margină, A Ungurianu, C Purdel… - Food and chemical …, 2020 - Elsevier
Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular
disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non …

The under-reported role of toxic substance exposures in the COVID-19 pandemic

RN Kostoff, MB Briggs, AL Porter, AF Hernández… - Food and chemical …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed
almost exclusively as virology problems, with toxicology problems mostly being ignored …

Preclinical and clinical results regarding the effects of a plant-based antidiabetic formulation versus well established antidiabetic molecules

A Ungurianu, O Şeremet, E Gagniuc, OT Olaru… - Pharmacological …, 2019 - Elsevier
Diabetes mellitus (DM) is a complex syndrome with debilitating long-term complications,
comprising alterations of carbohydrate, protein and lipid metabolisms, along increased …

[HTML][HTML] Zinc status, insulin resistance and glycoxidative stress in elderly subjects with type 2 diabetes mellitus

D Grădinaru, D Margină… - Experimental and …, 2021 - spandidos-publications.com
Zinc deficiencies have been reported in numerous pathologies, such as diabetes mellitus,
but also in the physiological process of ageing. Similarly, the end products of glycoxidation …

Interleukins and redox impairment in type 2 diabetes mellitus: mini-review and pilot study

A Ungurianu, A Zanfirescu, D Grădinaru… - Current Medical …, 2022 - Taylor & Francis
Background Type 2 diabetes mellitus (T2DM) represents a leading cause of morbidity and
premature mortality, low-grade inflammation being acknowledged as a key contributor to its …

[HTML][HTML] Tub and β-catenin play a key role in insulin and leptin resistance-induced pancreatic beta-cell differentiation

M Ercin, S Sancar-Bas, S Bolkent… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The aim of this study was to investigate the molecular mechanism of pancreatic islet-derived
mesenchymal stem cell (PID-MSC) differentiation into beta-cells in the presence of insulin …

The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals

S Dzięgielewska-Gęsiak, K Wyszomirska… - Science …, 2021 - journals.sagepub.com
In elderly, hormones and oxidant-antioxidant interplay are suggested to mediate
biochemical balance between adipose tissue to other tissues. Thus the study attempts to …