Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple
disorders, including neurodegenerative and autoimmune diseases as well as cancer. The …

Cells respond to invading pathogens and danger signals from the environment by adapting
gene expression to meet the need for protective effector molecules. While this innate …

The development of inflammation is mutually affected with damaged DNA and the abnormal
expression of protein modification. Ubiquitination, a way of protein modification, plays a key …

Procaspase-8 is a key mediator of death receptor (DR)-mediated pathways. Recently, the
role of post-translational modifications (PTMs) of procaspase-8 in controlling cell death has …

To elucidate the mechanisms for reverse LV remodeling, we generated a conditional
(doxycycline [dox] off) transgenic mouse tetracycline transactivating factor–TRAF2 (tTA …

Apoptosis is an evolutionary conserved cell death mechanism, which requires activation of
initiator and effector caspases. The Drosophila initiator caspase Dronc, the ortholog of …

The silk gland of the silkworm Bombyx mori is a specialized organ where silk proteins are
efficiently synthesized under precise regulation that largely determines the properties of silk …

HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), is a
critical regulator of inflammation. However, how HOIP itself is regulated to control …

Abstract The H2A. Z variant histone 1 (H2AZ1) is aberrantly expressed in various tumors,
correlating with an unfavorable prognosis. However, its role in hepatocellular carcinoma …

To investigate the regulation of endothelial cell (EC) microRNAs (miRNAs) altered by heat
stress, miRNA microarrays and bioinformatics methods were used to determine changes in …