Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases
CG Schalkwijk, CDA Stehouwer - Physiological reviews, 2020 - journals.physiology.org
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …
[HTML][HTML] The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Y Peng, SL Felce, D Dong, F Penkava, AJ Mentzer… - Nature …, 2022 - nature.com
Abstract NP105–113-B* 07: 02-specific CD8+ T cell responses are considered among the
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
Escherichia coli as a host for metabolic engineering
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
Radio signals from live cells: the coming of age of in-cell solution NMR
A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …
fundamental in order to understand diseases and to develop novel drugs and therapeutic …
The therapeutic potential of metformin in neurodegenerative diseases
C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …
today's aging population and an increasing burden on individuals, families, and society …
Mechanistic targeting of advanced glycation end-products in age-related diseases
S Rowan, E Bejarano, A Taylor - … et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …
[HTML][HTML] Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease
N Rabbani, PJ Thornalley - Biochemical and biophysical research …, 2015 - Elsevier
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to
increased protein and DNA modification contributing to cell and tissue dysfunction in ageing …
increased protein and DNA modification contributing to cell and tissue dysfunction in ageing …
The role of dietary advanced glycation end products in metabolic dysfunction
D Sergi, H Boulestin, FM Campbell… - Molecular Nutrition & …, 2021 - Wiley Online Library
Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …
produced, non‐enzymatically, from the interaction between reducing sugars and the free …
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …