Striatal circuits for reward learning and decision-making
The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …
those actions. Decades of experimental and theoretical work have led to several influential …
[HTML][HTML] The basal ganglia over 500 million years
S Grillner, B Robertson - Current Biology, 2016 - cell.com
The lamprey belongs to the phylogenetically oldest group of vertebrates that diverged from
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …
[HTML][HTML] The striatum organizes 3D behavior via moment-to-moment action selection
Many naturalistic behaviors are built from modular components that are expressed
sequentially. Although striatal circuits have been implicated in action selection and …
sequentially. Although striatal circuits have been implicated in action selection and …
The spatiotemporal organization of the striatum encodes action space
Activity in striatal direct-and indirect-pathway spiny projection neurons (SPNs) is critical for
proper movement. However, little is known about the spatiotemporal organization of this …
proper movement. However, little is known about the spatiotemporal organization of this …
Spatially compact neural clusters in the dorsal striatum encode locomotion relevant information
An influential striatal model postulates that neural activities in the striatal direct and indirect
pathways promote and inhibit movement, respectively. Normal behavior requires …
pathways promote and inhibit movement, respectively. Normal behavior requires …
The place of dopamine in the cortico-basal ganglia circuit
SN Haber - Neuroscience, 2014 - Elsevier
The midbrain dopamine (DA) neurons play a central role in developing appropriate goal-
directed behaviors, including the motivation and cognition to develop appropriate actions to …
directed behaviors, including the motivation and cognition to develop appropriate actions to …
Striatal local circuitry: a new framework for lateral inhibition
DA Burke, HG Rotstein, VA Alvarez - Neuron, 2017 - cell.com
This Perspective will examine the organization of intrastriatal circuitry, review recent findings
in this area, and discuss how the pattern of connectivity between striatal neurons might give …
in this area, and discuss how the pattern of connectivity between striatal neurons might give …
Control of basal ganglia output by direct and indirect pathway projection neurons
BS Freeze, AV Kravitz, N Hammack… - Journal of …, 2013 - Soc Neuroscience
The direct and indirect efferent pathways from striatum ultimately reconverge to influence
basal ganglia output nuclei, which in turn regulate behavior via thalamocortical and …
basal ganglia output nuclei, which in turn regulate behavior via thalamocortical and …
[HTML][HTML] Dopamine is required for the neural representation and control of movement vigor
Progressive depletion of midbrain dopamine neurons (PDD) is associated with deficits in the
initiation, speed, and fluidity of voluntary movement. Models of basal ganglia function focus …
initiation, speed, and fluidity of voluntary movement. Models of basal ganglia function focus …
Complementary contributions of striatal projection pathways to action initiation and execution
The performance of an action relies on the initiation and execution of appropriate movement
sequences. Two basal ganglia pathways have been classically hypothesized to regulate this …
sequences. Two basal ganglia pathways have been classically hypothesized to regulate this …