Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a
mechanism by which cholesterol metabolism controls the development and differentiation of …

Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection
against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding …

The TGF-β family comprises many structurally related differentiation factors that act through
a heteromeric receptor complex at the cell surface and an intracellular signal transducing …

Transforming growth factor β (TGFβ) pathways are implicated in metazoan development,
adult homeostasis and disease. TGFβ ligands signal via receptor serine/threonine kinases …

During the past 10 years, it has been firmly established that Smad pathways are central
mediators of signals from the receptors for transforming growth factor β (TGF-β) superfamily …