The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

The content of proteoglycans (PGs) is low in the extracellular matrix (ECM) of vascular
tissue, but increases dramatically in all phases of vascular disease. Early studies …

Seaweed-derived polysaccharides including agar and alginate, have found widespread
applications in biomedical research and medical therapeutic applications including wound …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

The incidence of myocardial infarction (MI) increases every year worldwide. Better
diagnostic and prognostic biomarkers for clinical applications are the consistent pursuit of MI …

Fluid shear stresses are potent regulators of vascular homeostasis and powerful
determinants of vascular disease progression. The glycocalyx is a layer of …

Objective—Factors and mechanisms that activate macrophages in atherosclerotic plaques
are incompletely understood. We examined the capacity of heparanase to activate …

Objectives: The study interrogated an autopsy registry to investigate the histopathologic
features of early stent thrombosis (ST) in patients presenting with acute coronary syndrome …

Haemostasis encompasses a set of strictly regulated actions, such as vasoconstriction,
platelet activation and blood coagulation. Endothelial cells play a crucial role in all of these …

This review summarizes key developments in the heparanase field obtained 20 years prior
to cloning of the HPSE gene and nearly 20 years after its cloning. Of the numerous …