In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …

Camptothecin analogues and derivatives appear to exert their antitumour activity by binding
to topoisomerase I and have shown significant activity against a broad range of tumours. In …

Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian
cells and a potent inducer of strand breaks in chromosomal DNA. Neither the equilibrium …

Camptothecin, which induces an unusual type of DNA damage by trapping cellular
topoisomerase I on chromosomal DNA in the form of drug-enzyme-DNA cleavable …

We show that transcription of a DNA molecule inside a bacterium is accompanied by local
and temporal supercoiling of the DNA template: as transcription proceeds, DNA in front of …

By introduction of recombinant plasmids into monkey CV1 cells, we have unambiguously
demonstrated that sequences entirely within the 72 bp repeat, which is located upstream of …

Camptothecin, a cytotoxic antitumor compound, has been shown toproduce protein-linked
DNA breaks mediated bymammalian topoisomerase I. We have investigated the mechanism …

We have obtained a polyclonal antibody that recognizes a major polypeptide component of
chicken mitotic chromosome scaffolds. This polypeptide migrates in SDS PAGE with Mr …

Topotecan-or mitoxantrone-selected cell lines (T8 and MX3, respectively), derived from the
human IGROV1 ovarian cancer cell line, were resistant to the topoisomerase I inhibitors …

The nuclear enzyme topoisomerase I (topo I) has been recently recognized as the target for
the anticancer drug camptothecin (CPT) and its derivatives. Two of the agents that target this …