γ-Aminobutyric acid (GABA) signalling in plants
The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …
The glycinergic inhibitory synapse
P Legendre - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …
brainstem, and glycinergic synapses have a well-established role in the regulation of …
Functional domains of GABAA receptors
GB Smith, RW Olsen - Trends in pharmacological sciences, 1995 - cell.com
The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the
neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids …
neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids …
The glycine receptor
The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor
superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective …
superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective …
A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse
SG Ryan, MS Buckwalter, JW Lynch, CA Handford… - Nature …, 1994 - nature.com
Hereditary hyperekplexia, an autosomal dominant neurologic disorder characterized by an
exaggerated startle reflex and neonatal hypertonia, can be caused by mutations in the gene …
exaggerated startle reflex and neonatal hypertonia, can be caused by mutations in the gene …
[HTML][HTML] Identification of a [3H] muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit.
GB Smith, RW Olsen - Journal of Biological Chemistry, 1994 - Elsevier
An amino acid which appears to be involved in an agonist binding site of the gamma-
aminobutyric acid type A (GABAA) receptor protein has been identified by photoaffinity …
aminobutyric acid type A (GABAA) receptor protein has been identified by photoaffinity …
Mutation of glutamate 155 of the GABAA receptor β2 subunit produces a spontaneously open channel: a trigger for channel activation
JG Newell, RA McDevitt, C Czajkowski - Journal of Neuroscience, 2004 - Soc Neuroscience
Protein movements underlying ligand-gated ion channel activation are poorly understood.
The binding of agonist initiates a series of conformational movements that ultimately lead to …
The binding of agonist initiates a series of conformational movements that ultimately lead to …
The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
A loop structure, formed by the putative disulfide bridging of Cys198 and Cys209, is a
principal element of the ligand binding site in the glycine receptor (GlyR). Disruption of the …
principal element of the ligand binding site in the glycine receptor (GlyR). Disruption of the …
Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor
The glycine receptor is a member of the ligand-gated ion channel receptor superfamily that
mediates fast synaptic transmission in the brainstem and spinal cord. Following ligand …
mediates fast synaptic transmission in the brainstem and spinal cord. Following ligand …
[HTML][HTML] Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel
P Li, EM Slimko, HA Lester - FEBS letters, 2002 - Elsevier
Glutamate-gated chloride (GluCl) channels from invertebrates can be activated by
ivermectin (IVM) to produce electrical silencing in mammalian neurons. To improve this …
ivermectin (IVM) to produce electrical silencing in mammalian neurons. To improve this …