Chemical inhibition of sterol biosynthesis
Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …
Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex
MT Romano, A Tafazzoli, M Mattern… - The American Journal of …, 2018 - cell.com
Hypotrichosis simplex (HS) is a rare form of hereditary alopecia characterized by childhood
onset of diffuse and progressive scalp and body hair loss. Although research has identified a …
onset of diffuse and progressive scalp and body hair loss. Although research has identified a …
[HTML][HTML] Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice
Understanding how individuals react differently to the same treatment is a major concern in
precision medicine. Metabolic challenges such as the one posed by high fructose intake are …
precision medicine. Metabolic challenges such as the one posed by high fructose intake are …
Molecular modeling and in vitro study on pyrocatechol as potential pharmacophore of CD151 inhibitor
M Akella, RR Malla - Journal of Molecular Graphics and Modelling, 2020 - Elsevier
CD151 has been recognized as a prognostic marker, the therapeutic target of breast
cancers, but less explored for small molecule inhibitors due to lack of a validated model. The …
cancers, but less explored for small molecule inhibitors due to lack of a validated model. The …
Rational design of selective HDAC2 inhibitors for liver cancer treatment: computational insights into the selectivity mechanism through molecular dynamics simulations …
Y Yang, B Hu, Y Yang, K Gong, H Wang… - Physical Chemistry …, 2021 - pubs.rsc.org
The rational design of selective histone deacetylase 2 (HDAC2) inhibitors is beneficial for
the therapeutic treatment of liver cancer, though HDAC2 is highly homologous to HDAC8 …
the therapeutic treatment of liver cancer, though HDAC2 is highly homologous to HDAC8 …
Structural basis for tailor-made selective PI3K α/β inhibitors: a computational perspective
H Wang, Y Wang, C Li, H Wang, X Geng, B Hu… - New Journal of …, 2021 - pubs.rsc.org
PI3K α and β are Class IA PI3K isoforms that share a highly homologous ATP binding site,
differing only in a few residues around the binding site. They are ubiquitously expressed in …
differing only in a few residues around the binding site. They are ubiquitously expressed in …
Effects of Fdft 1 gene silencing and VD3 intervention on lung injury in hypoxia-stressed rats
X Pu, X Lin, Y Qi, Y Li, T Li, Y Liu, D Wei - Genes & Genomics, 2022 - Springer
Background Hypoxia can induce lung injury such as pulmonary arterial hypertension and
pulmonary edema. And in the rat model of hypoxia-induced lung injury, the expression of …
pulmonary edema. And in the rat model of hypoxia-induced lung injury, the expression of …
Computer-aided drug design, synthesis and identification of disulfide compounds as novel and potential allosteric PAK1 inhibitors
H Huang, H Jiang, X Zhang, W Li, P Wang, F Liu… - RSC …, 2018 - pubs.rsc.org
p21-activated kinase 1 (PAK1) is an evolutionarily conserved serine/threonine protein
kinase, which has been considered as one of the key regulatory factors in signaling network …
kinase, which has been considered as one of the key regulatory factors in signaling network …
[PDF][PDF] Educational Qualification
MSR Naik - 1965 - vidyawarta.com
Profile of Dr. Poornima G. Naik Page 1 BIO-DATA Name : Dr.Poornima Girish Naik Designation :
Professor Educational Qualificat Page 1 Profile of Dr. Poornima G. Naik Page 1 BIO-DATA Name …
Professor Educational Qualificat Page 1 Profile of Dr. Poornima G. Naik Page 1 BIO-DATA Name …