[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

LM O'Connor, BA O'Connor, SB Lim, J Zeng… - Journal of …, 2023 - Elsevier
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives

S Lista, R González-Domínguez, S López-Ortiz… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …

[HTML][HTML] Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: review and recommendations

L Krishaa, TKS Ng, HN Wee, J Ching - Mechanisms of Ageing and …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people
worldwide. Growing evidence suggests that the gut microbiome (GM) plays a pivotal role in …

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome

Y Jin, J Chi, K LoMonaco, A Boon, H Gu - TrAC Trends in Analytical …, 2023 - Elsevier
As it is well known, the gut is one of the primary sites in any host for xenobiotics, and the
many microbial metabolites responsible for the interactions between the gut microbiome and …

Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects

J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

Advancing personalized medicine: Integrating statistical algorithms with omics and nano-omics for enhanced diagnostic accuracy and treatment efficacy

A Coskun, G Ertaylan, M Pusparum, R Van Hoof… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Medical laboratory services enable precise measurement of thousands of biomolecules and
have become an inseparable part of high-quality healthcare services, exerting a profound …

[HTML][HTML] Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projects

S Rischke, L Hahnefeld, B Burla, F Behrens… - Journal of mass …, 2023 - Elsevier
Mass spectrometry focusing on small endogenous molecules has become an integral part of
biomarker discovery in the pursuit of an in-depth understanding of the pathophysiology of …

Multiplatform untargeted metabolomics

MJ Jeppesen, R Powers - Magnetic Resonance in Chemistry, 2023 - Wiley Online Library
Metabolomics samples like human urine or serum contain upwards of a few thousand
metabolites, but individual analytical techniques can only characterize a few hundred …

Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer's Disease Patients?

B Talavera Andújar, A Mary, C Venegas… - … science & technology, 2024 - ACS Publications
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease, which
is currently diagnosed via clinical symptoms and nonspecific biomarkers (such as Aβ1–42, t …

[HTML][HTML] Advances in peripheral blood biomarkers of patients with Alzheimer's disease: Moving closer to personalized therapies

G Ferretti, S Serafini, A Angiolillo, P Monterosso… - Biomedicine & …, 2023 - Elsevier
Recently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's
disease (AD) have gained considerable clinical interest. Several studies have identified one …