Human membrane drug transporters are recognized as major actors of pharmacokinetics;
they also handle endogenous compounds, including hormones and metabolites. Chemical …

The ATP-dependent membrane transporter P-glycoprotein (P-gp) is associated with
resistance to a wide variety of chemical substrates, as well as the multi-drug resistance …

The membrane efflux transporter P-glycoprotein (P-gp,[ABCB1, MDR1]) exports a wide
range of xenobiotic compounds, resulting in a continuous first line of defense against …

Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-
glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2). However, little …

Environmental health science seeks to predict how environmental toxins, chemical toxicants,
and prescription drugs accumulate and interact within the body. Xenobiotic transporters of …

An organism's diet is a major route of exposure to both beneficial nutrients and toxic
environmental chemicals and natural products. The uptake of dietary xenobiotics in the …

The teleost ATP Binding Cassette (ABC) transporter P-glycoprotein (P-gp) is an active
transmembrane transporter that plays a pivotal role in facilitating the movement of both …

Transmembrane transporter proteins facilitate an essential biological role in all living
organisms by regulating the movement of substances across lipid membranes. The ABC …

Exposure to environmental pollutants or xenobiotics is often toxic to fish, reducing their
ability to develop, grow, reproduce, or survive. While variation among fish species in their …

Environmental chemicals can affect the world's food quality and quantity in multiple ways.
There is increasing evidence for chemical contamination of food and water, such as …