Interest in the tumour suppressor p53 has generated much information regarding the
complexity of its function and regulation in carcinogenesis. However, gaps still exist in our …

Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

Hepatitis C virus (HCV) encodes a single polyprotein, which is processed by cellular and
viral proteases to generate 10 polypeptides. The HCV genome also contains an …

Hepatitis C virus (HCV) core, known to be involved in liver carcinogenesis, is processed in
the endoplasmic reticulum (ER). We thus investigated the impact of three HCV core isolates …

Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th
cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core …

IFN-α production by plasmacytoid dendritic cells (PDCs) is critical in antiviral immunity. In the
present study, we evaluated the IFN-α-producing capacity of PDCs of patients with chronic …

Since the discovery of the hepatitis C virus (HCV) as the causative agent of non-A, non-B
hepatitis, significant effort has been devoted to understanding this important pathogen …

Background & Aims: Persistent inflammation contributes to progression of liver damage in
chronic HCV (cHCV) infection. Repeated exposure to toll-like receptor (TLR) ligands results …

The building block of hepatitis C virus (HCV) nucleocapsid, the core protein, together with
viral RNA, is composed of different domains involved in RNA binding and homo …

Chronic hepatitis C virus (HCV) infection has a significantly increased prevalence of type 2
diabetes mellitus (T2DM). Insulin resistance is a critical component of T2DM pathogenesis …