Deubiquitinases in cancer
G Dewson, PJA Eichhorn, D Komander - Nature Reviews Cancer, 2023 - nature.com
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers
How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …
[HTML][HTML] Control of cell metabolism by the epidermal growth factor receptor
LA Orofiamma, D Vural, CN Antonescu - Biochimica et Biophysica Acta …, 2022 - Elsevier
The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …
Discovery of KB-0742, a potent, selective, orally bioavailable small molecule inhibitor of CDK9 for MYC-dependent cancers
DB Freeman, TD Hopkins, PJ Mikochik… - Journal of Medicinal …, 2023 - ACS Publications
Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …
Deciphering the Role of the Ser‐Phosphorylation Pattern on the DNA‐Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis
The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …
Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
S Edman, RG Jones III, PR Jannig… - EMBO …, 2024 - embopress.org
A detailed understanding of molecular responses to a hypertrophic stimulus in skeletal
muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the …
muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the …
PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
A Gaballa, A Gebhardt-Wolf, B Krenz… - Nature …, 2024 - nature.com
In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …
G1 Dynamics at the Crossroads of Pluripotency and Cancer
D Fleifel, JG Cook - Cancers, 2023 - mdpi.com
Simple Summary The cell division cycle is tightly regulated to ensure faithful and complete
DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in …
DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in …
MYC function and regulation in physiological perspective
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …
that regulates almost every physiological process in a cell including cell cycle, proliferation …