Many functions of telomerase components: Certainties, doubts, and inconsistencies
A growing number of studies have evidenced non-telomeric functions of “telomerase”.
Almost all of them, however, investigated the non-canonical effects of the catalytic subunit …
Almost all of them, however, investigated the non-canonical effects of the catalytic subunit …
Telomere-related DNA damage response pathways in cancer therapy: prospective targets
L Gu, M Liu, Y Zhang, H Zhou, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Maintaining the structural integrity of genomic chromosomal DNA is an essential role of
cellular life and requires two important biological mechanisms: the DNA damage response …
cellular life and requires two important biological mechanisms: the DNA damage response …
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity
M Machitani, A Nomura, T Yamashita, M Yasukawa… - Nature Cell …, 2024 - nature.com
As aberrant accumulation of RNA–DNA hybrids (R-loops) causes DNA damage and
genome instability, cells express regulators of R-loop structures. Here we report that RNA …
genome instability, cells express regulators of R-loop structures. Here we report that RNA …
Photo-induced telomeric DNA damage in human cancer cells
Herein we report on the study of novel dinuclear ruthenium (II) complexes designed to target
and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently …
and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently …
Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity
B Maliński, J Vertemara, E Faustini… - Human Molecular …, 2023 - academic.oup.com
Telomere biology disorders (TBDs) are characterized by short telomeres, premature aging,
bone marrow failure and cancer predisposition. Germline mutations in NHP2, encoding for …
bone marrow failure and cancer predisposition. Germline mutations in NHP2, encoding for …
Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly
J Song, C Castillo-González, Z Ma… - Nucleic Acids …, 2021 - academic.oup.com
The recent discovery of the bona-fide telomerase RNA (TR) from plants reveals conserved
and unique secondary structure elements and the opportunity for new insight into the …
and unique secondary structure elements and the opportunity for new insight into the …
The multifaceted hTR telomerase RNA from a structural perspective: Distinct domains of hTR differentially interact with protein partners to orchestrate its telomerase …
M Raghunandan, A Decottignies - BioEssays, 2021 - Wiley Online Library
Human telomerase progressively emerged as a multifaceted ribonucleoprotein complex with
additional functions beyond telomeric repeat synthesis. Both the hTERT catalytic subunit …
additional functions beyond telomeric repeat synthesis. Both the hTERT catalytic subunit …
Detection of alternative lengthening of telomeres mechanism on tumor sections
E Claude, G de Lhoneux, CE Pierreux, E Marbaix… - Molecular …, 2021 - Springer
The vast majority of adult cancer cells achieve cellular immortality by activating a telomere
maintenance mechanism (TMM). While this is mostly achieved by the de-silencing of h TERT …
maintenance mechanism (TMM). While this is mostly achieved by the de-silencing of h TERT …
[HTML][HTML] A novel mutation (p. Y24N) in NHP2 leads to idiopathic pulmonary fibrosis and lung carcinoma chronic obstructive lung disease by disrupting the expression …
L Liu, Y Sheng, CY Wang, X Liu, T Guo, H Peng… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a kind of chronic interstitial lung disease and can be
caused by mutations in NHP2 ribonucleoprotein (NHP2), a component of the telomerase …
caused by mutations in NHP2 ribonucleoprotein (NHP2), a component of the telomerase …