3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA
molecules in real time. To address this problem and to allow the purification of fluorescently …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Asymmetric localization of oskar ribonucleoprotein (RNP) granules to the oocyte posterior is
crucial for abdominal patterning and germline formation in the Drosophila embryo. We show …

Subcellular localization of messenger RNAs (mRNAs) can give precise control over where
protein products are synthesized and operate. However, just 10 years ago many in the …

The localization of RNAs critically contributes to many important cellular processes in an
organism, such as the establishment of polarity, asymmetric division and migration during …