Background The long reads produced by third generation sequencing technologies have
significantly boosted the results of genome assembly but still, genome-wide assemblies …

Abstract Motivation: The de Bruijn graph has become a ubiquitous graph model for
biological data ever since its initial introduction in the late 1990s. It has been used for a …

Background With long reads getting even longer and cheaper, large scale sequencing
projects can be accomplished without short reads at an affordable cost. Due to the high error …

Background De novo genome assembly typically produces a set of contigs instead of the
complete genome. Thus additional data such as genetic linkage maps, optical maps, or Hi-C …

Sequencing the entire human genome has been an ambitious endeavor, culminating in the
recent achievement of a gapless human genome sequence in 2022. While this …

Optical mapping is a method for creating high resolution restriction maps of an entire
genome. Optical mapping has been largely automated, and first produces single molecule …

Optical mapping is a method for creating high resolution restriction maps of an entire
genome. Optical mapping has been largely automated, and first produces single molecule …

With long reads getting even longer and cheaper, large scale sequencing projects can be
accomplished without short reads at an affordable cost. Due to the high error rates and less …

Optical maps are high resolution restriction maps that give a unique numeric representation
to a genome. Used in concert with sequence reads, they provide a useful tool for genome …