Report of the expert committee on the diagnosis and classification of diabetes mellitus

Expert Committee on the Diagnosis and … - Diabetes …, 2003 - Am Diabetes Assoc
The current classification and diagno-sis of diabetes used in the US was developed by the
National Diabetes Data Group (NDDG) and published in 1979 (1). The impetus for the …

Non-insulin-dependent diabetes mellitus—a genetically programmed failure of the beta cell to compensate for insulin resistance

KS Polonsky, J Sturis, GI Bell - New England Journal of Medicine, 1996 - Mass Medical Soc
Non-insulin-dependent diabetes mellitus (NIDDM), the commonest form of diabetes, affects
approximately 5 percent of the population of the United States. Although the …

Report of the expert committee on the diagnosis and classification of diabetes mellitus

JR Gavin III, K Alberti, MB Davidson… - Diabetes …, 1997 - search.proquest.com
The current classification and diagnosis of diabetes used in the US was developed by the
National Diabetes Data Group (NDDG) and published in 1979 (1). The impetus for the …

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

K Yamagata, N Oda, PJ Kaisaki, S Menzel, H Furuta… - Nature, 1996 - nature.com
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

Diabetes mellitus and its treatment

S Bastaki - International journal of Diabetes and Metabolism, 2005 - karger.com
Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion,
insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycaemia with …

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

MT Malecki, US Jhala, A Antonellis, L Fields, A Doria… - Nature …, 1999 - nature.com
The helix-loop-helix (HLH) protein NEUROD1 (also known as BETA2) functions as a
regulatory switch for endocrine pancreatic development. In mice homozygous for a targeted …

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha and 4 alpha in maturity‐onset diabetes of the young and hyperinsulinemic …

K Colclough, C Bellanne‐Chantelot… - Human …, 2013 - Wiley Online Library
Maturity‐onset diabetes of the young (MODY) is a monogenic disorder characterized by
autosomal dominant inheritance of young‐onset (typically< 25 years), noninsulin …

[HTML][HTML] Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene

A Bonnefond, J Philippe, E Durand, A Dechaume… - PloS one, 2012 - journals.plos.org
Background Maturity-onset of the young (MODY) is a clinically heterogeneous form of
diabetes characterized by an autosomal-dominant mode of inheritance, an onset before the …

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction

H Ræder, S Johansson, PI Holm, IS Haldorsen, E Mas… - Nature …, 2006 - nature.com
Dysfunction of the exocrine pancreas is observed in diabetes, but links between concurrent
exocrine and endocrine pancreatic disease and contributing genetic factors are poorly …

Monogenic diabetes: Implementation of translational genomic research towards precision medicine: 单基因糖尿病: 应用翻译基因组研究朝精准医疗迈进

M Vaxillaire, P Froguel - Journal of Diabetes, 2016 - Wiley Online Library
摘要目前已经认识到了各种类型早期发病的非自身免疫性糖尿病是单基因糖尿病,
每种亚型都是在个体水平上发生的高度变异的单一基因缺陷所导致的. 单基因糖尿病 …