Several major diseases, such as cancer and cardiovascular abnormalities, may be linked to
pathological deposition of minerals or organic compounds in various tissues. 1− 3 Thus, the …

Patients with bone and cartilage defects due to infection, tumors, and trauma are quite
common. Repairing bone and cartilage defects is thus a major problem for clinicians …

Studies on various compounds of inorganic phosphate, as well as on organic phosphate
added by post-translational phosphorylation of proteins, all demonstrate a central role for …

A major challenge for cartilage tissue engineering remains the proper integration of
constructs with surrounding tissues in the joint. Biphasic osteochondral constructs that can …

Integration of in vitro-formed cartilage on a suitable substrate to form tissue-engineered
implants for osteochondral defect repair is a considerable challenge. In healthy cartilage, a …

Background: Chondrocyte migration in native cartilage is limited and has been implicated as
one of the reasons for the poor integration of native implants. Through use of an in vitro …

We aimed to examine the presence of Zn, a trace element, in osteoarthritis (OA) cartilage
and meniscus from patients undergoing total knee joint replacement for primary OA. We …

Clinical utilization of tissue-engineered cartilage constructs has been limited by their inferior
mechanical properties compared to native articular cartilage. A number of strategies have …

Calcium polyphosphate is a biodegradable bone substitute. It remains a challenge to
prepare porous calcium polyphosphate with desired gradient porous structures. In this study …

Drug delivery into articular cartilage poses many challenges due in part to its lack of
vasculature. While intra‐articular injections are effective for the local administration of drugs …