2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the …

K Zeppenfeld, J Tfelt-Hansen, M De Riva… - European heart …, 2022 - academic.oup.com
4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Management of ventricular arrhythmias worldwide: comparison of the latest ESC, AHA/ACC/HRS, and CCS/CHRS guidelines

H Könemann, C Ellermann, K Zeppenfeld… - Clinical …, 2023 - jacc.org
A new guideline for the management of patients with ventricular arrhythmias and the
prevention of sudden cardiac death has been published by the European Society of …

Inherited arrhythmias in the pediatric population: an updated overview

MV Mariani, N Pierucci, F Fanisio, D Laviola, G Silvetti… - Medicina, 2024 - mdpi.com
Pediatric cardiomyopathies (CMs) and electrical diseases constitute a heterogeneous
spectrum of disorders distinguished by structural and electrical abnormalities in the heart …

Primary Electrical Heart Disease—Principles of Pathophysiology and Genetics

K Badura, D Buławska, B Dąbek, A Witkowska… - International Journal of …, 2024 - mdpi.com
Primary electrical heart diseases, often considered channelopathies, are inherited genetic
abnormalities of cardiomyocyte electrical behavior carrying the risk of malignant arrhythmias …

A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells

M Yavuz, T Demircan - Molecular Biology Reports, 2023 - Springer
Background Despite recent advances in drug discovery, cancer is still one of the most lethal
health problems worldwide. In most cases, standard therapy methods and multi-modal …

Preclinical short QT syndrome models: Studying the phenotype and drug-screening

X Fan, G Yang, J Kowitz, F Duru, AM Saguner… - EP …, 2022 - academic.oup.com
Cardiovascular diseases are the main cause of sudden cardiac death (SCD) in developed
and developing countries. Inherited cardiac channelopathies are linked to 5–10% of SCDs …

The effect of hydroquinidine on proliferation and apoptosis of TMZ-sensitive and-resistant GBM Cells

M Yavuz, T Demircan - Anti-Cancer Agents in Medicinal …, 2023 - ingentaconnect.com
Background: Glioblastoma multiforme (GBM) is a lethal form of central nervous system
cancer with a lack of efficient therapy options. Aggressiveness and invasiveness of the GBM …

Latent causes of sudden cardiac arrest

AD Krahn, J Tfelt-Hansen, R Tadros, C Steinberg… - Clinical …, 2022 - jacc.org
Inherited arrhythmia syndromes are a common cause of apparently unexplained cardiac
arrest or sudden cardiac death. These include long QT syndrome and Brugada syndrome …

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes

KH Jæger, S Wall, A Tveito - PLoS computational biology, 2021 - journals.plos.org
Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT
interval of the patient's electrocardiogram. The syndrome is associated with increased risk of …

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome

Z Zhao, X Zang, K Niu, W Song, X Wang, A Mügge… - …, 2024 - thelancet.com
The clinical significance of optimal pharmacotherapy for inherited arrhythmias such as short
QT syndrome (SQTS) and long QT syndrome (LQTS) has been increasingly recognised. The …