SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Stimulator of interferon genes (STING) is an essential adaptor protein required for the
inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mainly involving
synovial inflammation and articular bone destruction. RA is a heterogeneous disease with …

Conspectus Proteins are well-known to undergo a variety of post-translational modifications
(PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group …

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

Activity-based protein profiling (ABPP) has emerged as a powerful and versatile tool to
enable annotation of protein functions and discovery of targets of bioactive ligands in …

Background: Peptidyl arginine deiminase 4 (PAD4) is an enzyme that converts arginine into
citrulline. PAD4 is expressed in neutrophils that, when activated, can drive the formation of …